The study shows no negative effect of the SARS-CoV-2 BNT162b2 vaccination on male fertility

The researchers analyzed the sperm parameters of men undergoing fertility treatment and found no effect of the vaccine against the severe acute respiratory syndrome BNT162b2 mRNA coronavirus 2 (SARS-CoV-2).

To combat the COVID-19 pandemic, many countries have launched mass vaccination programs. These vaccines were approved after several safety trials. However, its effect on fertility is still unknown. However, vaccination is still recommended for people planning to conceive.

Several studies have found a negative influence of SARS-CoV-2 on the sperm parameters. In addition, the gonads can also be susceptible to SARS-CoV-2 infections.

Researchers from the Hebrew University of Jerusalem studied the effects of the Pfizer / BioNTech BNT162b2 mRNA vaccine on male fertility and reported their results in an article published on the medRxiv * preprint server.

The sperm parameters do not change after vaccination

The researchers collected data from all patients at an in vitro fertilization center between February and March 2021 after vaccination began in Israel. The team reviewed the medical records of 43 vaccinated male patients and compared the data before vaccination and an average of 33 days after the first vaccination dose.

They found no difference in the various sperm parameters they analyzed, such as sperm volume and sperm concentration. Patients included patients with male infertility and normosperm.

These initial results show no negative effect of mRNA vaccination on male fertility.

“Our study is the first to evaluate the impact of the BNT162b2 vaccine on sperm parameters. Each patient, who served as their own control, increased the accuracy and showed that this vaccine did not appear to have any effect on the sperm parameters. These preliminary results are reassuring to the young male population vaccinated around the world. Given that SARS-CoV-2 infection can affect male fertility, we recommend vaccination for couples planning to become pregnant, as vaccination will not affect sperm, while SARS-CoV-2 Infection affects sperm, ”the authors write.

* Important NOTE

medRxiv publishes preliminary scientific reports that are not peer-reviewed and therefore should not be considered conclusive, guide clinical practice / health-related behavior, or treated as established information.

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